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By Car from Florence :
1) Highway A11 (Florence-Mare) direction PISA, Pisa North Exit. Drive along the SS1-Aurelia in direction of Pisa Center - Pisa Central Station
2) Highway Florence Pisa Livorno continue for Pisa, Exit Pisa Central – Pisa Airport, continue towards Pisa Station Central.

By Train :
Pisa Central Station is only 100 m from the " Michele Guest House ".
There are many direct routes on the Turin-Genova-Rome and Livorno-Florence lines. Other direct routes are from Milan Central. From Bologna, you can change at Florence to reach Pisa. Trains run every hour, throughout the day, from and towards Florence.

http://www.trenitalia.com/en/

By Air :
“Galileo Galilei” International Airport, the principal step of Central Italy along with Roma Airport, is located only 2000 metres from the Guest House, and offers flights to and from all the main international airports of Europe everyday.

http://www.pisa-airport.it